The keyboard shortcuts only work when they are enabled—that is, when the button with a picture of some keys is pressed down. When it is not pressed, the keys work as normal—this allows you to type the character that key would normally have typed, or access functions in your program that the key would normally have accessed.
Enabled:
Disabled:
On some keyboards the right-hand ‘Alt’ key (sometimes labelled ‘Alt Gr’) works as a combination of the Ctrl and Alt keys: pressing RightAlt+A is the same as pressing Alt+A.
Keyboard shortcuts are always turned off when you have any of the FrKeys settings windows open, to avoid confusion.